MatriStem® Pelvic Floor Matrix for Pelvic Organ Prolapse

What is MatriStem?

MatriStem Pelvic Floor Matrix is a tissue-based product that is used during surgery for pelvic floor repair and during various other surgical procedures. MatriStem provides the body with a scaffold containing a collection of collagens and proteins that allow the body’s cells to integrate naturally into the site of repair. Over time, MatriStem is completely replaced with tissue that is similar to normal vaginal wall tissue, without foreign material permanently left in your body.

What Are MatriStem Devices Made Of?

MatriStem is a naturally-occurring product made from the bladder of pigs (porcine derived), which becomes more similar to human tissue after processing to remove its cells. The use of porcine tissue for medical purposes has been established for more than 40 years. MatriStem is processed and sterilized to ensure that no animal-based disease is present in the material.

How Is MatriStem Pelvic Floor Matrix Different Than Synthetic Mesh?

Upon implantation, MatriStem surgical devices reinforce the weakened area and allows the formation of new tissue through the body’s own constructive remodelling process that provides support to the surrounding pelvic organs. Unlike a synthetic mesh which is left permanently in the body, MatriStem is resorbed and replaced with tissue that is similar to normal vaginal tissue.

Will There Be Any Side Effects Or Possible Complications With The Use Of MatriStem Pelvic Floor Matrix?

Complications and reactions are possible with any surgery, and with any surgical repair of tissue. Possible complications and side effects can include: infection, increased chronic inflammation, allergic reaction, unexplained fever or chills, excessive redness, acute and chronic pain, swelling, tender scars, adhesions, seroma formation, pain during sex, inability to have sex (vaginal shortening), vaginal bleeding, atypical vaginal discharge, groin and/or buttock and/or leg pain, fistula formation, trouble controlling your bladder or not being able to empty your bladder, fecal incontinence, injury to the bladder, bowel, blood vessels, and/or nerves of the pelvis, permenant nerve injury, delayed or failed incorporation of graft, failure to repair your prolapse, recurrent prolapse (return to your original prolapse) and mesh or suture erosion or extrusion. Other unknown side effects and complications can also occur. Talk to your surgeon for more information.

What Can I Expect Following Surgery With MatriStem Pelvic Floor Matrix?

You may experience pelvic pain and vaginal discharge following surgery. This may be associated with tissue healing and the product beginning the remodeling process. As with most vaginal prolapse surgery, healing takes around three months. During this time you should avoid any activity that can put pressure or strain on the repaired area, such as lifting, straining, vigorous exercise, coughing, constipation and intercourse. Please consult with your doctor regarding the specifics of your restrictions following surgery and when it is safe to resume these activities.


How it Works

Repairing a Cystocele

MatriStem is positioned between the bladder and vaginal wall. The product is attached to internal structures with sutures to return your bladder to its proper position. Once in place, the body will begin to remodel the MatriStem to repair the weakened tissues.


Repairing a Rectocele

MatriStem is inserted through a small incision in the vagina and positioned between the rectum and vaginal wall. The product is attached to internal structures with sutures to return your rectum to its proper position. Once in place, the body will begin to remodel the MatriStem to repair the weakened tissues.